The research reveals IGF-1R as a differential regulator of two different modes of transmission - spontaneous and evoked - in hippocampal circuits of the brain. A new Tel Aviv University study finds that the insulin-like growth factor 1 receptor (IGF-1R), the “master” lifespan regulator, plays a vital role in directly regulating the transfer and processing of information in hippocampal neural circuits. Hyperactivity of the hippocampus is known to be associated with conditions that confer risk for AD, including amnestic mild cognitive impairment. Understanding precisely how a “healthy” brain stores and processes information is crucial to preventing and reversing the memory failures associated with Alzheimer’s disease (AD), the most common form of late-life dementia. The mechanisms underlying the stability and plasticity of neural circuits in the hippocampus, the part of the brain responsible for spatial memory and the memory of everyday facts and events, has been a major focus of study in the field of neuroscience. TAU links growth factor to development of Alzheimer’s disease
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